Mrs Hume handed away in Londonderry following a brief sickness on Thursday.
Mrs Clinton and her husband Invoice made a number of visits to Northern Ireland Throughout their first go to in 1995, shortly after the IRA ceasefires, they visited Derry and walked throughout the town’s Peace Bridge with the Humes.
Mrs Clinton tweeted: “Pat Hume was a gracious, decided power behind the achievement of peace in Eire.
“She and her husband John each made the world a greater place and set an instance for us all. Sending my condolences to her household.”
DUP chief Sir Jeffrey Donaldson mentioned that Pat Hume had lived a “distinctive life”.
He mentioned: “My deepest sympathies to the Hume household on the loss of life of Pat Hume. A singular life properly lived and nobody who met John left the dialog with out realizing Pat. A beautiful woman.”
Sinn Fein president Mary Lou McDonald, mentioned she had been left “deeply saddened” by the information.
She added: “I prolong my deepest condolences to her household and pals. She shall be sadly missed by her youngsters, prolonged household and pals, colleagues and the individuals of Derry.”
Alliance Social gathering chief Naomi Lengthy mentioned Mrs Hume’s dedication to peace “was complete”.
She mentioned: “Very sorry to listen to Pat Hume has handed away – an absolute woman, heat & pleasant, at all times encouraging. Her dedication to peace was complete as was her dedication to John esp. in his latter years.”
Ulster Unionist chief Doug Beattie tweeted: “Though we by no means met I’m saddened by the loss of life of Pat Hume. My ideas are with her household.”
Irish President Michael D Higgins mentioned Pat Hume had made an “extraordinary contribution to life on this island and past”.
He added: “The lifetime of Pat Hume was certainly one of complete dedication to neighborhood, to the chances of peace, to the measures of non-violence that had been crucial to claim, vindicate and obtain the outcomes of civil rights.
“Whereas her help of the work of her late husband and Nobel Prize recipient, John Hume, was an train in solidarity, a partnership in braveness, endurance and fortitude, her private contribution was distinctive, immense and essential in its personal proper.
“Pat’s private contribution as instructor, mom, in circumstances of battle, political adviser, constituency secretary and consoler of the victims of oppression from so many sources, was extraordinary in each sense.”
She was the rock behind the person who rightly has been credited because the architect of our present peace
Bishop of Derry Donal McKeown mentioned Pat Hume was “small in stature, however a colossus” in Irish historical past.
He added: “She was the rock behind the person who rightly has been credited because the architect of our present peace.
“In the midst of that lengthy and difficult journey in direction of the peace we take pleasure in at present Pat was courageous, brave and uncompromising, but she was at all times mild and profound in respect for different individuals and their opinions.”