Right-back Wan-Bissaka has been a key performer for Ole Gunnar Solskjaer thus far this season, however was pressured to withdraw from the England squad.
The 21-year-old picked up a again downside, with his membership team-mate Jesse Lingard additionally despatched residence from the England camp.
Illness pressured Lingard to sit down out the worldwide fixtures in opposition to Bulgaria and Kosovo, whereas left-back Shaw is struggling with a hamstring downside.
Pogba withdrew from the France squad with an ankle downside. Upfront, Martial missed United’s final sport in opposition to Southampton after selecting up a knock within the defeat to Crystal Palace final month.
United welcome Leicester City to Old Trafford of their first sport again after the worldwide break on the hunt for their first win since early August.
Solskjaer is underneath stress to provide outcomes after a massively promising 4-Zero opening day victory over Chelsea.
The enthusiasm for the brand new season rapidly subsided as United adopted that consequence up with a draw with Wolves earlier than slumping to their first residence defeat of the season in opposition to Palace.
Leicester are on of simply three Premier league sides nonetheless unbeaten, whereas United are languishing in eighth place after 4 video games.